For you search query Promethazine we found around 112468 songs. We may show you only some of them on this page. Promethazine oral tablet is a prescription drug used to treat several conditions. These include allergies, motion sickness, nausea and vomiting, anxiety before. Promethazine HCL. Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions.